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Metoprolol and Bupropion Interaction: A Case Study

NCJ Number
310112
Author(s)
D. Moody; R. Backman
Date Published
2014
Length
2 pages
Annotation

This paper presents the case of a man who experienced a drug interaction after being prescribed 150 mg of bupropion hydrochloride, with the effect of causing dyspnea, discussing the specific effect that the inhibition can have on metoprolol.

Abstract

Drug interactions can result in serious adverse responses. These are the ones practitioners most want to avoid. Responses may also be mild and not a serious health threat. Mild responses, however, may still cause consternation to the subject. Here, the authors present a case of a mild interaction that may have gone unexplained if the subject had not taken time to read a recent review on drug interactions. While the potential for brachycardia to ensue from co-administration of bupropion and metoprolol has been previously described, the authors wish to illustrate how a low dose of bupropion and metoprolol can cause an interaction that disrupts a patient’s daily activity. (Published Abstract Provided)