Gene-Environment Studies and Borderline Personality Disorder: A Review

• NCJ Number: 240721
• Journal: Current Psychiatry Reports Volume: 15 Issue: 1 Dated: January 2013
• Author(s): Ryan W. Carpenter; Rachel L. Tomko; Timothy J. Trull; Dorret I. Boomsma
• Date Published: January 2013
• Length: 7 pages
• Publication Format: Article
• Publication Type: Research (Applied/Empirical)
• Language: English
• Country: United States of America

Annotation

This study reviewed recent gene-environment studies relevant to borderline personality disorder, including those focusing on impulsivity, emotion sensitivity, suicidal behavior, aggression and anger, and the borderline personality phenotype itself.

Abstract

The authors review recent gene-environment studies relevant to borderline personality disorder, including those focusing on impulsivity, emotion sensitivity, suicidal behavior, aggression and anger, and the borderline personality phenotype itself. Almost all the studies reviewed suffered from a number of methodological and statistical problems, limiting the conclusions that currently can be drawn. The best evidence to date supports a gene-environment correlation (rGE) model for borderline personality traits and a range of adverse life events, indicating that those at risk for BPD are also at increased risk for exposure to environments that may trigger BPD. The authors provide suggestions regarding future research on GxE interaction and rGE effects in borderline personality. Abstract published by arrangement with Springer.