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Cautionary Note on the Evaluation of Genetic Evidence From Uniparentally Transmitted Markers

NCJ Number
225058
Journal
Forensic Science International: Genetics Volume: 2 Issue: 4 Dated: September 2008 Pages: 376-378
Author(s)
Antonio Amorim
Date Published
September 2008
Length
3 pages
Annotation
This paper challenges the recent proposal to combine into a single likelihood ratio the combination of information obtained from lineage genetic markers and the non-homologous region of Y-chromosome, with data resulting from meiotically recombining loci into a single likelihood ratio.
Abstract
This paper challenges the assumption that it is possible to combine the genetic data from both types of markers into a single likelihood ratio. This paper demonstrates that although the genetic evidence obtained from these markers is appropriate for individual probability calculations, mitochondrial DNA (mtDNA) and nhY data are not; consequently, joining the evidential value of the two types of markers is generally inconsistent. The combination of likelihood ratios from the two sources of data should be avoided, since it is generally inconsistent, is statistically heterogeneous, and is prone to strong biases. In contrast, reporting separately the results of the analyses from the two types of evidence, along with the distinct theoretical and statistical frameworks underlying them, is a sound way to avoid misunderstandings in presenting evidence in court. The assumption of noninvolvement of relatives must be clearly and explicitly stated, and its acceptance must be left to the court. 23 references