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Antisaccade Task Performance Deficit and Specific CNV Abnormalities in Patients with Stereotyped Paraphilia and Schizophrenia

NCJ Number
246189
Journal
Journal of Forensic Sciences Volume: 58 Issue: 5 Dated: September 2013 Pages: 1219-1226
Author(s)
Anna V. Kirenskaya; Maxim Y. Kamenskov Ph.D.; Vadim V. Myamlin Ph.D.; Vladimir Y. Novototsky-Vlasov Ph.D.; Andrey A. Tkachenko
Date Published
September 2013
Length
8 pages
Annotation
Antisaccade task performance and mean amplitudes of slow cortical potentials contingent negative variationCNV were investigated in 19 healthy volunteers, 16 schizophrenic patients SP, and 12 patients with stereotyped form of paraphilia PP.
Abstract
Antisaccade task performance and mean amplitudes of slow cortical potentials contingent negative variationCNV were investigated in 19 healthy volunteers, 16 schizophrenic patients SP, and 12 patients with stereotyped form of paraphilia PP. Compared with healthy subjects, schizophrenic and paraphilic patients committed significantly more erroneous saccades. The clear between-group CNV differences were observed during the early CNV stage that is associated with cognitive aspects of preparatory set. In SP, as compared to controls, the significant decline of CNV amplitude was found at frontal-central area. PP have demonstrated the lack of CNV over central and parietal regions, but their CNV amplitudes in frontal area did not differ from values of control group. Thus, two distinct types of CNV abnormalities have been found. The SP results have been interpreted as support for frontal dysfunction in schizophrenia. The disconnection between prefrontal cortex, sensorimotor cortex, and related subcortical structures is hypothesized in paraphilia group. Abstract published by arrangement with Wiley.

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