Antisaccade Task Performance Deficit and Specific CNV Abnormalities in Patients with Stereotyped Paraphilia and Schizophrenia

• NCJ Number: 246189
• Journal: Journal of Forensic Sciences Volume: 58 Issue: 5 Dated: September 2013 Pages: 1219-1226
• Author(s): Anna V. Kirenskaya; Maxim Y. Kamenskov Ph.D.; Vadim V. Myamlin Ph.D.; Vladimir Y. Novototsky-Vlasov Ph.D.; Andrey A. Tkachenko
• Date Published: September 2013
• Length: 8 pages
• Publication Format: Article
• Publication Type: Report (Study/Research)
• Language: English
• Country: United States of America

Annotation

Antisaccade task performance and mean amplitudes of slow cortical potentials contingent negative variationCNV were investigated in 19 healthy volunteers, 16 schizophrenic patients SP, and 12 patients with stereotyped form of paraphilia PP.

Abstract

Antisaccade task performance and mean amplitudes of slow cortical potentials contingent negative variationCNV were investigated in 19 healthy volunteers, 16 schizophrenic patients SP, and 12 patients with stereotyped form of paraphilia PP. Compared with healthy subjects, schizophrenic and paraphilic patients committed significantly more erroneous saccades. The clear between-group CNV differences were observed during the early CNV stage that is associated with cognitive aspects of preparatory set. In SP, as compared to controls, the significant decline of CNV amplitude was found at frontal-central area. PP have demonstrated the lack of CNV over central and parietal regions, but their CNV amplitudes in frontal area did not differ from values of control group. Thus, two distinct types of CNV abnormalities have been found. The SP results have been interpreted as support for frontal dysfunction in schizophrenia. The disconnection between prefrontal cortex, sensorimotor cortex, and related subcortical structures is hypothesized in paraphilia group. Abstract published by arrangement with Wiley.