The interpretation of complex DNA profiles is facilitated by a Bayesian approach. This approach requires the development of a pair of propositions, one aligned to the prosecution case and one to the defense case. A set of guidelines generalize how to formulate propositions when there is a single person of interest and when there are multiple individuals of interest. Additional explanations cover how to handle multiple defense propositions, relatives, and the transition from sub-source level to activity-level propositions. The propositions depend on case information and the allegations of each of the parties. The prosecution proposition is usually known. The authors suggest that a sensible proposition is selected for the defense that is consistent with their stance, if available, and consistent with a realistic defense if their position is not known. (Publisher abstract modified)
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