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An Efficient Ambient Ionization Mass Spectrometric Approach to Detection and Quantification of the Mescaline Content of Commonly Abused Cacti from the Echinopsis Genus

NCJ Number
Journal of Forensic Sciences Dated: 2019
Date Published
January 2020
6 pages
This article reports on a DART-HRMS approach for the rapid detection of mescaline in whole plant material and a validated method for the quantification of mescaline in cactus tissue, using mescaline-d9 as the internal standard.

Unregulated cacti from the genus Echinopsis are used recreationally as mescaline-containing alternatives to the outlawed peyote. Echinopsis-derived plant materials appear in a variety of nondescript forms, which requires rapid assessment of whether they are mescaline-containing materials or simply innocuous plant-derived food products. In the current project, calibration curves exhibited R2 values of greater than or equal to 0.995, and the method exhibited a LLOQ and a linear range of 1 ppm and 1 degrees C100 ppm, respectively. Application of the method to commercially available Echinopsis spp. yielded results consistent with previous studies performed by GC- and LC- MS, with mescaline levels of <2 percent dry weight in all cases. Project researchers conclude that DART-HRMS is a suitable technique for the rapid screening of mescaline and its subsequent quantification within complex plant derived matrices. (publisher abstract modified)

Date Published: January 1, 2020