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Commentary On: Thompson WC. Uncertainty in Probabilistic Genotyping of Low Template DNA: A Case Study Comparing STRmix™ and TrueAllele™

NCJ Number
Journal of Forensic Sciences Volume: 69 Issue: 1 Dated: 2024 Pages: 371-377
Date Published

This letter to the editor provides a link to the original article as well as the author’s response, in addition to the detailed comments on five specific points, citing doubts about the storage and handling of evidence discussed in the initial article that indicate a source-level conclusion would be of limited value at the activity level described.


The authors of this brief article focus their response to the initial article, commenting on five specific topics: whether the analytical threshold (AT) should be varied in casework, “To learn more about the consequences of applying a threshold”; why TrueAllele® and STRmix™ give different answers; whether the number of contributors (NoC) should automatically be varied across the plausible range; the upper bound is the correct bound to report if the LR is below one; and what one should do with multiple LRs. The authors of this article provide specific citations to the initial article and support their arguments with sources that are listed in the References section.

Date Published: January 1, 2024