Variability of the Entire Mitochondrial DNA Control Region in a Human Isolate From the Pas Valley (Northern Spain)

• NCJ Number: 232565
• Journal: Journal of Forensic Sciences Volume: 55 Issue: 5 Dated: September 2010 Pages: 1196-1201
• Author(s): Sergio Cardoso, Ph.D.; Maria T. Zarrabeitia, Ph.D.; Laura Valverde, B.Sc.; Adrian Odriozola, B.Sc.; Miguel A. Alfonso-Sanchez, Ph.D.; Marian M. de Pancorbo, Ph.D.
• Date Published: September 2010
• Length: 6 pages
• Publication Format: Article
• Publication Type: Report (Study/Research)
• Language: English
• Country: United States of America

Annotation

This study analyzed the entire mtDNA control region in 61 unrelated individuals from the Pas Valley (Cantabria), a human isolate from northern Spain, to evaluate the suitability of this analysis to increase the power of discrimination of this locus for forensic purposes in human isolates.

Abstract

Low values obtained for the diversity parameters confirmed the relative isolation of this human group. The main findings of this study indicated that even the analysis of the entire mtDNA control region may have important limitations for use in forensic casework when dealing with human isolates: none of the 44 individuals who exhibited identical HVI-HVII haplotypes could be further differentiated by analysis of segment HVIII. Nevertheless, analysis of the entire mtDNA control region proved to be useful to determine the ancestry of the samples examined, by contributing to the confirmation, and, on occasion, even to the refinement of the haplogroup assignment. (Published Abstract)