Use of Dynamically Coated Capillaries for the Routine Analysis of Methamphetamine, Amphetamine, MDA, MDMA, MDEA, and Cocaine Using Capillary Electrophoresis

• NCJ Number: 191311
• Journal: Journal of Forensic Sciences Volume: 46 Issue: 5 Dated: September 2001 Pages: 1025-1032
• Author(s): Ira S. Lurie M.S.; M. Jason Bethea B.S.; Timothy D. McKibben M.S.; Patrick A. Hays B.S.; Paolo Pellegrini Ph.D.; Raghvendra Sahai Ph.D.; Agnes D. Garcia B.S.; Robert Weinberger Ph.D.
• Date Published: September 2001
• Length: 8 pages
• Publication Format: Article
• Publication Type: Research (Applied/Empirical)
• Language: English
• Country: United States of America

Annotation

This paper described the qualitative and quantitative analysis of amphetamine, methamphetamine, MDA, MDMA, MDEA, and cocaine in seized drugs using dynamically coated capillaries.

Abstract

This paper presented the routine analysis of methamphetamine, amphetamine, MDA, MDMA, MDEA, and cocaine in seized drugs through a rapid, accurate, precise, economically, and environmentally gentle method using capillary electrophoresis (CE). The methodology used a 32 cm by 50 um capillary with a commercially available buffer kit and diode array UV detection. Using this methodology, amphetamine, methamphetamine, MDA, MDMA, MDEA, and an internal standard were baseline resolved in less than 5 minutes. None of the compounds usually encountered in illicit samples interfered with the target compound or the internal standard. Quantitative results for synthetic mixtures and seized exhibits were in good agreement with actual values and with results obtained from other techniques. The relatively high electroosmotic flow (EOF) for the dynamically coated capillary system allowed for the screening of basic, acidic, and neutral adulterants in drug seizures; identification was facilitated by the use of automated UV library searches. Tables, graphs, and references