This report describes the first ever application of GCxGC in cocaine profiling and the second one in heroin profiling to date.
This report examines whether comprehensive two-dimensional (2D) gas chromatography is suitable for routine use in a forensic laboratory for profiling illicit substances. Chapter 1 examines world anti-doping agency criteria for anabolic agent analysis using comprehensive two-dimensional gas chromatography/mass spectrometry. Steroid analysis by GCxGC was used as a model study to determine whether the method would comply with the strict and demanding analytical protocol for substances tested in athletes as determined by the World Anti-Doping Agency (WADA). Chapter 2 examines organic impurity profiling of ecstasy tablets using GCxGC analysis of illicit substances that are of concern to police jurisdictions, such as ecstasy, heroin and cocaine. Chapter 3 examines the application of GCxGC analysis of heroin and cocaine as an alternative to current profiling methods. GCxGC analysis offers a relatively simple, yet highly informative method for cocaine and heroin sample discrimination. This results in a complex profile that includes many other sample constituents that give additional information. Tables, figures, references, and appendixes