NEW METHODOLOGY FOR THE DETECTION OF NARCOTICS- FINAL REPORT

• NCJ Number: 2305
• Author(s): ANON
• Date Published: 1972
• Length: 79 pages
• Grant Number(s): NI-71-088
• Sponsoring Agency: US Dept of Justice; US Dept of Justice NIJ Pub
• Corporate Author: Huntingdon Research Center
• Sale Source: National Institute of Justice/
• Publication Type: Report (Study/Research)
• Language: English
• Country: United States of America

Annotation

QUANTITATIVE EVIDENCE OF MORPHINE UTILIZATION BY SYNTHETIC ENZYMES AS A METHOD OF NARCOTIC LEVEL DETECTION IN BODY FLUIDS OF SUSPECTED ADDICTS.

Abstract

THE SPECIFIC AIM OF THIS STUDY WAS TO ISOLATE BACTERIA OR FUNGI CAPABLE OF SYNTHESIZING ADAPTIVE ENZYMES WITH METABOLIC ACTIVITY VERSUS THE MORPHINE SUBSTRATE. EVIDENCE FOR THE PRODUCTION OF SUCH INDUCED ENZYMES WAS TO BE THE ABILITY OF THE ORGANISMS TO GROW IN A MINIMAL MEDIUM IN WHICH MORPHINE SULFATE WAS THE SOLE CARBON AND NITROGEN SOURCE. QUANTITATIVE EVIDENCE FOR MORPHINE UTILIZATION WAS ALSO TO BE PROVIDED BY THE DEVELOPMENT OF OF A SENSITIVE CHEMICAL PROCEDURE FOR MEASURING THE PROGRESSIVE DISAPPEARANCE OF THE MORPHINE SUBSTRATE FROM THE CULTURE MEDIUM IN WHICH THE MICROBIAL GROWTH WAS OBTAINED. (AUTHOR ABSTRACT)